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May 27, 2014
07:09 EDTVSTMVerastem publishes data on targeting mesothelioma cancer stem cells
Verastem announced that a paper, entitled “Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship,” has been published by Verastem scientists in the latest issue of the journal Science Translational Medicine. The paper describes the finding that loss of the tumor suppressor merlin predicts for increased responsiveness to drugs targeting cancer stem cells through inhibition of focal adhesion kinase.
News For VSTM From The Last 14 Days
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August 27, 2015
08:28 EDTVSTMVerastem weakness overdone, says JMP Securities
After Verastem reported that 24% of the KRAS-mutated NSCLC patients in a study of its FAK inhibitor defactinib had experienced serious adverse events, JMP Securities notes that it did not ascribe any valuation for the drug as a treatment for this indication. Moreover, the firm does not believe that the study affects the outlook for the drug in other settings, and it says that, given the patients' late stage status, deaths among the participants "would not be seen as an anamoly." JMP adds that the drug met its primary endpoint in the study. JMP reiterates a $23 price target and Outperform rating on the shares.
August 26, 2015
16:26 EDTVSTMOn The Fly: Top stock stories for Wednesday
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15:16 EDTVSTMVerastem says VS-6063 results under embargo, believes study has met goals
Verastem issued the following statement in response to inquiries regarding the anticipated oral presentation of VS-6063 data from a Phase 2 study in patients with KRAS mutant non-small cell lung cancer, or NSCLC, at the 16th World Conference on Lung Cancer: "While updated results from the Phase 2 study of VS-6063 in KRAS mutant non-small cell lung cancer are under embargo until WCLC, Verastem believes the study has met its goals, with encouraging outcomes that the company plans to explore in future studies. The population explored in this study has refractory, advanced lung cancer, with a median of three prior therapies, and as many as eight prior therapies. The advanced stage of disease led, in some cases, to deaths even in the period between screening and prior to first dose of VS-6063. Two subjects reported as having grade 5 respiratory failure were on multiple concomitant medications and presented with multiple co-morbidities. Both were thoroughly evaluated and reported to the regulatory authorities in 2013 and 2014 when they occurred. The totality of safety and efficacy data seen to date with VS-6063 across multiple clinical trials, multiple tumor types and stages of treatment is promising. In addition, in the company's registration-directed COMMAND trial in mesothelioma, an independent data safety monitoring board has met and reviewed study data, including adverse events, three times and recommended no changes to study protocol. There have been over 300 patients treated to date with VS-6063, including patients on drug for more than one year. Verastem remains encouraged by the clinical potential of targeting cancer stem cells through FAK inhibition, and is unwavering in its commitment to delivering novel, safe and effective treatments to patients with unmet medical needs."
11:55 EDTVSTMVerastem safety concerns on NSCLC data misplaced, says Mizuho
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11:43 EDTVSTMVerastem selloff on 'placeholder' abstract ignores key driver, says Roth Capital
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10:51 EDTVSTMVerastem shares defended at Roth Capital
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09:24 EDTVSTMVerastem to present data at World Conference on Lung Cancer
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August 20, 2015
05:48 EDTVSTMMizuho keeps TESARO, Verastem, OncoMed as top biotech picks
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