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Stock Market & Financial Investment News

News Breaks
April 25, 2012
07:12 EDTVICLVical coverage assumed with an Outperform at Credit Suisse
Target $5.
News For VICL From The Last 14 Days
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June 23, 2015
11:00 EDTVICLVical downgraded to Neutral from Buy at Roth Capital
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09:14 EDTVICLOn The Fly: Pre-market Movers
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June 22, 2015
19:00 EDTVICLOn The Fly: After Hours Movers
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17:08 EDTVICLVical down 45% after herpes vaccine study fails to meet primary endpoint
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16:12 EDTVICLVical reports top-line results from Phase 1/2 trial of genital herpes vaccine
Vical announced top-line results from an ongoing randomized, double-blind, placebo controlled Phase 1/2 clinical study of its therapeutic genital herpes vaccine, designed to reduce viral shedding and genital herpes lesions in herpes simplex virus type 2, or HSV-2, infected patients. The trial enrolled patients across seven U.S. sites and is evaluating two constructs: a monovalent, or gD, vaccine and a bivalent, or gD + UL46, vaccine, each formulated with Vical's proprietary Vaxfectin adjuvant. The top-line analysis compared pre-vaccination measurements for each arm with those taken during the swabbing period in months 2 and 3 following the last vaccine dose. Neither the monovalent nor bivalent vaccine met the primary endpoint. On prospectively defined secondary endpoints, the bivalent vaccine achieved statistically significant reductions in the rate of genital lesions and viral load from positive swabs versus baseline. Both the monovalent and bivalent vaccines were generally well tolerated. Safety data have been reviewed throughout the trial by an independent safety monitoring board, and no grade 4 adverse events or serious adverse events related to vaccination have been observed.

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