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February 5, 2014
07:04 EDTTRVNTrevena initiates TRV734 clinical development
Trevena announced the initiation of its first Phase 1 trial for TRV734. TRV734 is being developed to optimize analgesia while minimizing on-target gastrointestinal and respiratory effects through its novel biased ligand mechanism at the mu-opioid receptor. TRV734 takes advantage of the same receptor specificity mechanism as does Trevena’s Phase 2 clinical candidate, TRV130. The main objective of this first-in-human trial is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending doses of TRV734 in healthy subjects. The potentially efficacious dose range of TRV734 will also be evaluated using pupilometry, a validated biomarker for mu-opioid receptor engagement.
News For TRVN From The Last 14 Days
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May 21, 2015
09:58 EDTTRVNOn The Fly: Analyst Initiation Summary
Today's noteworthy initiations include: Alibaba (BABA) initiated with an Outperform at Bernstein... Alkermes (ALKS) initiated with an Overweight at Barclays... Burlington Stores (BURL) initiated with an Outperform at FBR Capital... Crocs (CROX) initiated with a Neutral at B. Riley... Darling (DAR) initiated with a Buy at Roth Capital... Dynegy (DYN) initiated with an Outperform at RBC Capital... Esperion (ESPR) initiated with an Overweight at Barclays... Five Below (FIVE) initiated with a Market Perform at FBR Capital... Intercept (ICPT) initiated with an Overweight, $450 target at Barclays... Johnson Matthey (JMPLY) initiated with a Buy at Jefferies... Nike (NKE) initiated with a Buy at Jefferies... RTI Surgical (RTIX) initiated with a Buy at Sidoti... TeleNav (TNAV) initiated with an Outperform at Northland... Trevena (TRVN) initiated with an Equal Weight at Barclays... Vectrus (VEC) initiated with a Hold at Stifel.
05:41 EDTTRVNTrevena initiated with an Equal Weight at Barclays
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May 14, 2015
07:08 EDTTRVNTrevena announces presentation of preclinical data for TRV250 program
Trevena announced that data highlighting its preclinical TRV250 program will be presented in an oral presentation at the International Headache Congress being held in Valencia, Spain, May 14-17, 2015. “Our preclinical data suggests TRV250 may safely activate the delta receptor in the central nervous system, and could become a first-in-class therapy for migraine and other CNS disorders,” said Maxine Gowen, Ph.D., CEO. “TRV250 is Trevena’s fourth biased ligand product candidate in development, which highlights the productivity of our platform in delivering differentiated new chemical entities targeting important unmet clinical needs.” Aimee Crombie, Ph.D., director of chemistry, will give an oral presentation entitled “TRV250: a novel biased ligand at the delta receptor for the potential treatment of migraine” in a session scheduled for 10:00 - 11:00 a.m. local time on Friday, May 15. The presentation will describe the preclinical profile of TRV250 and its actions at the delta opioid receptor, a CNS target with potential benefits in migraine and other CNS disorders. Previous efforts to develop selective delta receptor ligand drugs have been hindered by seizure risk which, in Trevena studies, was associated with delta receptor signals mediated by the scaffold protein β-arrestin2. Compared to previously described ligands, TRV250 elicits markedly reduced β-arrestin2 recruitment to the delta receptor. TRV250 is active in models of acute and chronic migraine as well as models of depression, anxiety, and pain, including pain associated with central sensitization. TRV250 displayed very broad safety margins in multiple preclinical species, and is not expected to have addiction or abuse liability associated with mu-opioid agonists like morphine and oxycodone.

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