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January 15, 2014
10:50 EDTTLOGTetraLogic rises 22% to $14.00
Strength in shares of Tetralogic (TLOG) has been at least partially attributed to the circulation of an article originally published Jan. 6 by The Cornell Chronicle regarding a study in which researchers destroyed metastasizing cancer cells by attaching a cancer-killer protein to white blood cells. The study process used TNF-related apoptosis-inducing ligand, or TRAIL, coated leukocytes, which is an area that TetraLogic is exploring in its research. The company also posted a new presentation to its website with technical information on its development pipeline. Reference Link
News For TLOG From The Last 14 Days
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April 21, 2015
08:15 EDTTLOGTetraLogic announces publication of papers describing birinapant activity in HBV
TetraLogic Pharmaceuticals announced that research describing birinapant's preclinical activity in a mouse model of chronic human hepatitis B virus, or HBV, has been published in the journal Proceedings of the National Academy of Sciences. The publication reports preclinical studies performed at the Walter and Eliza Hall Institute of Medical Research, or WEHI, Melbourne, Australia in collaboration with TetraLogic Pharmaceuticals. In studies performed by Dr. Marc Pellegrini and his colleagues in mouse models of human hepatitis B, administration of birinapant resulted in loss of HBV-DNA, loss of HBsAg and the appearance of anti-HBsAg antibodies. A second paper describes similar results in mice where the targets of birinapant, cIAP1 and cIAP2, were ablated in the liver. That result provides independent genetic confirmation of birinapant's mechanism of action. These experiments provided the scientific rationale for TetraLogic's ongoing multiple ascending dose study of birinapant in subjects with chronic HBV. The trial is being conducted in subjects over the age of 18 with chronic HBV who are receiving treatment with either tenofovir or entecavir and who are HBsAg positive.
April 20, 2015
08:05 EDTTLOGTetraLogic, Merck enter into oncology clinical study collaboration
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