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June 13, 2014
05:38 EDTTGTXTG Therapeutics reports compelling clinical data from TG-1101 Phase 2 study
TG Therapeutics announced preliminary clinical results from its ongoing Phase 2 study of TG-1101, the company's novel glycoengineered anti-CD20 monoclonal antibody, in combination with ibrutinib. The overall response rate, or ORR, at the first planned efficacy assessment for the 10 evaluable patients was 90%. Of the 28 patients enrolled on study to date, including patients with high risk CLL, no patients have progressed while on the combination, with patients on study now for upwards of 5 months. TG-1101 in combination with ibrutinib was well tolerated in the 28 patients evaluable for safety, with Day 1 infusion related reactions, or IRR, being the most frequently reported adverse event for TG-1101. Updated data presented at the EHA meeting demonstrates an 89% nodal response rate with 8/9 CLL patients now achieving a nodal or partial response on TGR-1202 monotherapy at doses greater than or equal to 800 mg.
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August 15, 2014
07:31 EDTTGTXTG Therapeutics commences clinical study that combines TG-1101, TGR-1202
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