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February 19, 2013
08:43 EDTPPHMPeregrine updates top-line data from Phase 2 clinical trial of Bavituximab
Peregrine Pharmaceuticals reported data from its randomized, double-blind placebo-controlled Phase II trial of bavituximab in patients with second-line non-small cell lung cancer, or NSCLC. Data from the trial has been updated based on completion of an earlier review of discrepancies in the trial and the most current survival data from the trial. Updated results from this Phase II trial indicate a meaningful improvement in median overall survival of 11.7 months in the 3mg/kg bavituximab + docetaxel arm compared to 7.3 months in the control arm. Persistent separation in the survival curves was observed with response rates and progression free survival also favoring the 3mg/kg bavituximab + docetaxel arm in this difficult to treat second-line NSCLC. The results also demonstrated that bavituximab was well-tolerated with no significant differences in adverse events between the trial arms. Peregrine plans to report additional data from the trial, including updated subgroup analysis and safety data, at an upcoming scientific meeting.
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April 8, 2014
07:22 EDTPPHMBiotech Industry Organization to hold a conference
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April 7, 2014
08:29 EDTPPHMPeregrine reports supporting data for combining bavituximab with irradiation
Peregrine Pharmaceuticals announced data from studies demonstrating that an equivalent antibody to Peregrine's lead immunotherapeutic antibody candidate bavituximab administered with stereotactic body radiation therapy, or SBRT, showed a 100% improvement in survival and favorable tumor eradication in a model of non-small cell lung cancer, or NSCLC, compared to irradiation alone. These data were presented yesterday at the 105th Annual Meeting of the American Association for Cancer Research, or AACR, being held in San Diego, California from April 5-9, 2014. Bavituximab is an investigational immunotherapy currently being evaluated in NSCLC as part of the SUNRISE pivotal Phase III clinical trial.
07:27 EDTPPHMAmerican Association of Cancer Research to hold annual meeting
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