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December 10, 2012
09:07 EDTOXGNOxigene presents encouraging OXi4503 preclinical and clinical data
Oxigene announced that investigators at the University of Florida presented encouraging clinical data using Oxigene's vascular disrupting agent, or VDA, OXi4503, in patients with acute myelogenous leukemia, or AML, at the annual meeting of the American Society of Hematology in Atlanta, Georgia. The data showed responses and a manageable safety profile in this first-in-man trial of a VDA in AML. Overall response was 2/5, or 40%, with 1 patient achieving a marrow complete remission, or mCR, and 1 patient achieving a partial remission. The median number of cycles was 1, in a range of 1-6. Three of 5 subjects discontinued the study due to AML progression and one due to pneumonia. One patient with AML treated with 5 mg/m2 OXi4503 has received 6 months of treatment and continues to receive weekly infusions.
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