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News Breaks
April 10, 2014
08:46 EDTONVOOrganovo says technology successfully fabricated 3D breast tissues in study
Organovo Holdings updated investors on the results of its initial study of 3D breast tissues generated with its NovoGen MMX Bioprinter in breast cancer models. The company presented these results at the annual meeting of the American Association for Cancer Research, or AACR, held on April 5-9. Results from the company’s initial study showed the NovoGen MMX Bioprinter technology can successfully fabricate 3D breast tissues consisting of cancer cells, fibrous stroma, adipose tissue, and microvasculature on a reproducible basis. Histologic and metabolic measurements highlighted a consistency in printing from construct to construct. The company’s experiments involving the delivery of fluorescently-tagged drugs to its 3D breast tissues indicate some drugs like methotrexate, which is small and hydrophilic, can fully penetrate its 3D bioprinted tissues, allowing assessment of the effects of drugs throughout the full thickness of the tissue. Other drugs, like paclitaxel, which is large and lipophilic, which are known to have trouble penetrating solid tumors due to dense stroma presence, charge, or other factors, are similarly modeled in the company’s 3D breast tissues. These early results from the company’s initial study confirm that the 2D culture systems were not effective in modeling drug responses in complex, multi-cellular tissue systems, like breast cancer. Furthermore, these early results suggest that utilizing 3D tissues may enable researchers to make compartment-specific assessments of drug response — something that is not currently possible outside of in vivo models to date.
News For ONVO From The Last 14 Days
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April 22, 2015
16:44 EDTONVOOn The Fly: Top stock stories for Wednesday
Stocks on Wall Street began the session in positive territory, but turned negative shortly after the open. The downside move failed to gain momentum and the averages remained near the flat line for most of the morning. The market moved to session highs by mid-afternoon and drifted higher into the close, as investors prepared for another round of earnings reports. ECONOMIC EVENTS: In the U.S., existing home sales rose 6.1% to a 5.19M rate in March, which was better than the expected 3.1% increase to a rate of 5.03M. Crude oil inventories built up by 5.32M barrels last week, which was more than the consensus forecast for a 3.2M barrel build. In Asia, Japan's Nikkei 225 average closed above 20,000 for the first time since April 2000. In Europe, Germany raised its economic growth forecast for 2015 to 1.8%, which was up from the 1.5% growth it said it expected in January. COMPANY NEWS: Shares of Visa (V) rose $2.66, or 4.07%, to $68.01 and MasterCard (MA) advanced $3.43, or 3.91%, to $91.20 after China's State Council announced overnight that the country will regulate the market access for bankcard transaction clearing institutions, which analysts think might allow both companies to compete for the processing of domestic transactions in the country. Goldman Sachs said the overall rule is broader and simpler than expected, raising the possibility that Visa and MasterCard could operate more freely in China than the firm had previously expected... Shares of McDonald's (MCD) advanced $2.97, or 3.13%, to $97.84 after the company reported headline earnings that missed expectations but also said it is developing a turnaround plan to improve its performance and deliver "enduring profitable growth" that it plans to share in the first week of May. MAJOR MOVERS: Among the notable gainers was Organovo (ONVO), which surged 67c, or 14.99%, to $5.14 after disclosing the company entered into a multi-year research collaboration agreement with Merck (MRK) that gives the drugmaker access to Organovo’s commercial exVive3D Human Liver Tissue service. Also higher was Vitamin Shoppe (VSI), which gained $5.54, or 14.22%, to $44.50 after asset management firm Carlson Capital revealed that it had obtained a 5.34% stake in the company and said that it had held talks with the retailer of natural treatments, supplements and vitamins. Among the noteworthy losers was Natural Resource Partners (NRP), which dropped $1.38, or 19.94%, to $5.54 after the company slashed its quarterly distribution by 75% to 9c per unit. Also lower were shares of Chipotle Mexican Grill (CMG), which fell $51.29, or 7.41%, to $641.23 after the company reported lower than expected first quarter comparable sales growth of 10.4%. INDEXES: The Dow rose 88.68, or 0.49%, to 18,038.27, the Nasdaq gained 21.07, or 0.42%, to 5,035.17, and the S&P 500 advanced 10.67, or 0.51%, to 2,107.96.
09:22 EDTONVOOn The Fly: Pre-market Movers
UP AFTER EARNINGS: CalAmp (CAMP), up 12.7%... Angie's List (ANGI), up 17.4%... Broadcom (BRCM), up 6.3%... Owens Corning (OC), up 3.8%... Yum! Brands (YUM), up 3.3%... Dolby Laboratories (DLB), up 3.6%... Infinera (INFN), up 2.4%... AutoNation (AN), up 2.5%... Amgen (AMGN), up 3.1%... Coca-Cola (KO), up 2%. ALSO HIGHER: Procera Networks (PKT) up 10.4% after being acquired by Francisco Partners in deal valued at $240M... Organovo (ONVO), up 19.2% after entering into a collaboration agreement with Merck Sharp and Dohme... Vical (VICL), up 5.8% after being awarded $4M contract to manufacture HIV vaccines for clinical evaluation... CTI BioPharma (CTIC), up 4.9% after announcing that Phase 3 pacritinib data will be highlighted in a late-breaking oral presentation at ASCO meeting. DOWN AFTER EARNINGS: Chipotle Mexican Grill (CMG), down 5.2%... iRobot (IRBT), down 3.6%... Cree (CREE), down 3.5%... United Rentals (URI), down 4%... Super Micro Computer (SMC), down 2.3%... Thermo Fisher (TMO), down 2.6%. ALSO LOWER: Natural Resource Partners (NRP), down 14% after reducing quarterly distribution 75% to 9c per unit... Trinity Industries (TRN), down 3.5% following a Bloomberg report that the Justice Department has initiated a criminal investigation into Trinity guardrails.
08:18 EDTONVOOrganovo enters into a collaboration agreement with Merck Sharp and Dohme
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April 21, 2015
17:08 EDTONVOOrganovo sees Q4 revenue $268,000, consensus $300,000.
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