Omeros announces positive OMS302 safety data in Phase 3 clinical trial Omeros announced the successful completion of the 90-day safety database lock in the second of the company's two pivotal Phase 3 clinical trials evaluating OMS302 in patients undergoing intraocular lens replacement surgery. OMS302 is Omeros' proprietary PharmacoSurgery product designed to maintain intraoperative mydriasis and reduce postoperative pain and irritation resulting from cataract and other lens replacement surgery. Safety data were collected through postoperative day 90. In this Phase 3 clinical trial, OMS302 was well tolerated. No safety concerns have been identified in the OMS302 clinical development program.
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Omeros' OMS824 for brain diseases shows positive Phase 2a results Omeros announced additional positive results from a Phase 2a clinical trial of OMS824, the company's phosphodiesterase 10 inhibitor. Patients with schizophrenia were administered a higher dose than had been evaluated in any OMS824 trial, which resulted in approximately 50% higher plasma concentrations than did the previously reported highest dose and had a similar side-effect profile to those of the lower doses. OMS824 selectively inhibits PDE10, an enzyme expressed in areas of the brain linked to a wide range of diseases that affect cognition, including schizophrenia and Huntington's disease. OMS824 was tolerated with mild or moderate adverse events that were consistent with those seen in previous cohorts, were self-limited and did not result in any discontinuation of the drug. An additional PET trial cohort is planned in the coming weeks.