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June 24, 2014
07:03 EDTOHRPOhr announces positive interim Phase II results of Squalamine eye drops
Ohr Pharmaceutical announced positive top-line interim results for its double-masked, placebo-controlled Phase II clinical trial of Squalamine eye drops in patients with wet age-related macular degeneration. The data demonstrated a positive benefit in visual function across multiple clinically relevant endpoints, including a mean change in visual acuity at the end of study visit for the interim analysis group of plus 10.4 letters with Squalamine eye drops plus Lucentis PRN versus plus 6.3 letters in the placebo eye drops plus Lucentis PRN arm. The visual acuity improvements were seen as early as four weeks and the relative difference in visual acuity between the two treatment arms continued to increase throughout the study. In the interim analysis, there were no significant differences in the frequency of Lucentis PRN injections, which was the primary endpoint of the study. The company plans to present the full data from this interim analysis at an ophthalmology conference in the 2H14, with final clinical trial data expected in the 1Q15.
News For OHRP From The Last 14 Days
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March 27, 2015
10:20 EDTOHRPOhr Pharmaceutical price target lowered to $15 from $25 at Cowen
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10:01 EDTOHRPHigh option volume stocks
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09:30 EDTOHRPOhr Pharmaceutical downgraded to Neutral from Buy at Chardan
Price target $8.
09:26 EDTOHRPOn The Fly: Pre-market Movers
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07:53 EDTOHRPOhr Pharmaceutical data better than may seem, says Brean Capital
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07:49 EDTOHRPOhr Pharmaceutical to host conference call
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07:14 EDTOHRPOhr Pharmaceutical announces final topline data from OHR-102 Phase II study
Ohr Pharmaceutical announced the topline results from the exploratory Phase II IMPACT study evaluating OHR-102 combination therapy for the treatment of the wet form of age-related macular degeneration, or wet-AMD. In the intent-to-treat, or ITT-LOCF population with classic containing choroidal neovascularization, or CNV, 42% of the patients receiving OHR-102 achieved a 3 line gain at nine months, as compared to 28% in the Lucentis monotherapy group. Less of a benefit was seen in the overall population. The classic containing CNV population represents approximately two thirds of the total wet-AMD population. The positive effect on visual acuity in classic CNV was seen early in the course of treatment and continued to increase through the end of the study, supporting the planned Phase III development program. In patients with classic CNV, mean gains in visual acuity were +10.5 letters for the OHR-102 combination arm and +5.4 letters with Lucentis monotherapy, a clinically meaningful benefit of +5.1 letters. The mean number of injections between the treatment arms, the primary endpoint of the study, was not meaningfully different.

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