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Stock Market & Financial Investment News

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June 26, 2014
10:23 EDTSWHC, MTOR, SBGI, VRTX, APOL, UNXL, OHRP, RMTI, NWBO, ACHNOptions with decreasing implied volatility
Options with decreasing implied volatility: OHRP VRTX ACHN UNXL SBGI NWBO APOL MTOR RMTI SWHC
News For OHRP;VRTX;ACHN;UNXL;SBGI;NWBO;APOL;MTOR;RMTI;SWHC From The Last 14 Days
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May 18, 2015
11:40 EDTACHNAchillion jumps after conference presentation cancelled
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May 17, 2015
13:46 EDTVRTXVertex reports Orkambi data, says 'significant improvements' in primary endpoint
Vertex Pharmaceuticals announced that the New England Journal of Medicine published data from the two phase 3 studies of Orkambi, or lumacaftor/ivacaftor, a medicine designed to treat the underlying cause of cystic fibrosis in people ages 12 and older with two copies of the F508del mutation. In November 2014, Vertex submitted an NDA to the FDA for the combination of lumacaftor and ivacaftor. On May 12th, the FDA’s Pulmonary Allergy Drugs Advisory Committee voted 12-1 to recommend approval of Orkambi for people ages 12 and older with two copies of the F508del mutation. The FDA is expected to make a decision by July 5. The New England Journal reports that the studies enrolled 1108 patients who underwent randomization and received Orkambi. In both studies, there were significant improvements in the primary end point in both lumacaftor–ivacaftor dose groups. The difference between active treatment and placebo with respect to the mean absolute improvement in the percentage of predicted FEV ranged 2.6%-4%, which corresponded to a mean relative treatment difference of 4.3 to 6.7%. Pooled analyses showed that the rate of pulmonary exacerbations was 30%-39% lower than in the placebo group. The rate of events leading to hospitalization or the use of intravenous antibiotics was also lower. The incidence of adverse events was generally similar to the placebo group.
May 15, 2015
09:31 EDTVRTXAmerican Thoracic Society to hold a conference
ATS 2015 Conference is being held in Denver on May 15-20.
May 13, 2015
07:19 EDTVRTXVertex shares should have upward momentum in near-term, says JMP Securities
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May 12, 2015
17:54 EDTVRTXOn The Fly: After Hours Movers
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16:49 EDTVRTXVertex resumes after-hours trading, shares up 5.6% to $131.00
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16:20 EDTVRTXVertex to resume trading at 14:45
16:19 EDTVRTXVertex confirms FDA panel voted 12-to-1 to recommend approval of Orkambi
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16:16 EDTVRTXVertex confirms FDA panel voted 12-to-1 to recommend approval of Orkambi
16:16 EDTVRTXPiper Jaffray remains confident in approval for Vertex
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15:43 EDTVRTXFDA panel votes 12 to 1 that data supports Orkambi approval
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15:35 EDTVRTXFDA panel votes unanimously that data support Orkambi safety
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15:35 EDTSBGISinclair Broadcast announces distribution deal with Chideo
Chideo announced a first-of-its-kind partnership with Sinclair Broadcast Group to expand Chideo's reach by 42 million households. Through this unique distribution deal, Sinclair will connect its broadcast and digital audience with Chideo's inspirational and entertaining content – all to benefit the world's leading charities. Sinclair's 161 local television stations will provide much-needed public awareness for these causes, as well as direct financial support from the sale of advertising and sponsorships around Chideo's rich collection of exclusive content from more than 100 celebrity ambassadors.
15:32 EDTVRTXFDA panel inconclusive on if Lumacaftor contributes to Orkambi effectiveness
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12:37 EDTAPOLFor-profit education stocks slide after SEC charges ITT with fraud
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10:23 EDTVRTXVertex shares halted while FDA panel meeting takes place
07:58 EDTVRTXFDA Pulmonary-Allergy Drugs Advisory Committee to hold a meeting
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May 11, 2015
16:14 EDTOHRPOhr Pharmaceutical reports Q2 net loss ($3.4M) vs.($2M) in Q214
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16:04 EDTUNXLUni-Pixel reports Q1 EPS (46c), consensus (44c)
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07:40 EDTVRTXFocus on Vertex will shift to pricing after Orkambi FDA meeting, WSJ says
An FDA advisory committee that meets Tuesday to decide whether to recommend approval of Vertex’s Orkambi will be closely watched by health insurers and pharmacy-benefit managers concerned that the experimental cystic-fibrosis drug will be high-priced, said The Wall Street Journal. Vertex hasn’t announced a price, but analyst at JPMorgan predict the drug will have a wholesale price of about $287,000 annually per patient. Publicly traded PBM owners include Catamaran (CTRX), which is being acquired by UnitedHealth (UNH), CVS Health (CVS) and Express Scripts (ESRX). Reference Link
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