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News Breaks
May 6, 2014
07:49 EDTOGEN, XONOragenics advancing towards identification of lead antibiotic clinical candidate
Oragenics (OGEN) announced that through its Exclusive Channel Collaboration with Intrexon Corporation (XON), it has produced and analyzed a large number of new potential analogs generated from its Mutacin 1140 antibiotic program platform, and advanced several promising compounds for further evaluation. These compounds will serve as the basis for selecting a lead drug candidate for clinical development later this year. The triaged analogs were selected from hundreds of variants generated using genetic engineering at Intrexon. Dr. John N. Bonfiglio, CEO of Oragenics, remarked, "The compounds we have selected for final evaluation align with our goal of identifying the first lead compound this year. We plan on meeting with the FDA later this year to discuss the IND enabling activities necessary to submit an IND application by mid-2015. Intrexon’s synthetic biology expertise in collaboration with our scientists has enabled generation of a large library of new potential MU1140 analogs with chemical and biological properties that differentiate from native MU1140. We remain very optimistic that these new lantibiotics will become useful in the fight against certain drug-resistant bacteria.”
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October 30, 2014
19:51 EDTOGENOragenics announces resignation of Dr. John Bonfiglio as CEO
Oragenics has announced that on October 30, Dr. John Bonfiglio resigned as CEO, president and director of Oragenics, Inc. to pursue other opportunities. During the interim period before a new CEO is hired, the board will provide direction to the company, with Dr. Frederick Telling acting as its liaison with management. Sullivan, the company’s current CFO, will serve as the company’s interim principal executive officer to address the vacancy created by Dr. Bonfiglio’s resignation. The board of has begun the process of finding a permanent successor to Dr. Bonfiglio.

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