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June 1, 2014
16:17 EDTNKTRNektar announces new data from Phase 2 study of NKTR-102
Nektar Therapeutics announced new data from an investigator-sponsored Phase 2 study of NKTR-102, etirinotecan pegol, in patients with Avastin-refractory high-grade glioma conducted at Stanford Cancer Institute under the direction of Lawrence Recht, M.D., Professor of Neurology and Neurosurgery, with co-investigator Seema Nagpal, M.D., Clinical Assistant Professor of Neurology and Neurological Sciences, Stanford School of Medicine. The primary endpoint was met and exceeded with fifty-five percent of patients in the study achieving six-week progression-free survival. Response and disease progression were assessed by RANO criteria in the trial. Three patients, or 15%, achieved partial responses with NKTR-102 monotherapy with maximum percent reductions in tumor area of 86%, 72%, and 59%. An additional eight patients, or 40%, achieved stable disease as best response. Two of the three patients with RANO responses experienced a long duration of response of 14 and 20 months. Secondary endpoints include median progression-free survival, median survival from time of first NKTR-102 infusion and median overall survival from date of pathologic diagnosis or confirmation of high-grade glioma. NKTR-102 monotherapy was well-tolerated in patients with Avastin-refractory high-grade glioma with low toxicity in spite of being heavily pre-treated and neurologically symptomatic. Only one patient had Grade 3 toxicity attributable to NKTR-102 as a result of not taking anti-diarrheal medication. Hematologic toxicity was mild. As of May 31, there is one patient in the study who is continuing on NKTR-102 monotherapy.
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October 20, 2014
11:12 EDTNKTRNektar management to meet with Roth Capital
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