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June 17, 2014
08:13 EDTMRTXMirati Therapeutic' mocetinostat granted ODD by FDA as treatment for MDS
Mirati Therapeutics announced that mocetinostat, the company's spectrum selective HDAC inhibitor, has been granted Orphan Drug Designation, or ODD, by the FDA as a treatment for myelodysplastic syndrome, or MDS. Mocetinostat is being developed in Phase 2 clinical studies in combination with Vidaza as a treatment for intermediate and high-risk MDS, as well as a single agent treatment in patients with diffuse large B-cell lymphoma and bladder cancer targeting specific genetic mutations in histone acetylation that increase the likelihood of response in tumor cells.
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May 13, 2015
17:23 EDTMRTXMirati Therapeutics to update pipeline programs at 2015 ASCO
Mirati Therapeutics announced that the company will provide an update on its investigational targeted tyrosine kinase inhibitor candidates, MGCD265 and MGCD516, and spectrum-selective HDAC inhibitor, mocetinostat, at the 2015 American Society of Clinical Oncology Annual Meeting to be held in Chicago from May 29-June 2, 2015. The updates on MGCD265 will be presented as part of the developmental therapeutics category. MGCD516 and mocetinostat will be presented as clinical trials in progress."We are pleased to participate in the 2015 ASCO Annual Meeting and present the progress we have made with each of Mirati's targeted oncology candidates," said Charles M. Baum, M.D., Ph.D., president and CEO, Mirati. "We look forward to providing new insights concerning the scientific basis and clinical utility of our lead candidate, MGCD265, for patients with non-small cell lung cancer who are diagnosed with MET- or Axl-driven tumors."

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