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News Breaks
June 2, 2014
08:15 EDTMACKMerrimack identifies heregulin as patient response biomarker for MM-121
Merrimack Pharmaceuticals reported that expression of heregulin, the principal ligand that binds to and activates the ErbB3 receptor, is associated with poor response to standard of care therapy for patients with platinum-resistant ovarian cancer, ER/PR+ HER2- breast cancer and EGFR wild-type non-small cell lung cancer. Heregulin-driven drug resistance pathways were found to be active in approximately 30-50% of patients tested. Results from three Phase 2 studies further showed that patients with heregulin-positive tumors experienced a statistically significant reduction in their risk of progression when they received a combination of MM-121 with their standard of care therapy as compared to patients who received the standard of care therapy alone. MM-121 is specifically designed to block heregulin binding to ErbB3. Top line data from these trials had previously been released. Detailed biomarker data for all three studies were presented at the American Society of Clinical Oncology Annual Meeting, May 30-June 3. Akos Czibere, MD, PhD, Senior Medical Director at Merrimack, said, "We look forward to advancing MM-121 into definitive studies that will allow us to prospectively screen patients for heregulin."
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September 8, 2014
16:06 EDTMACKMerrimack initiated with a Buy at Cantor
Target $16.

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