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June 2, 2014
08:15 EDTMACKMerrimack identifies heregulin as patient response biomarker for MM-121
Merrimack Pharmaceuticals reported that expression of heregulin, the principal ligand that binds to and activates the ErbB3 receptor, is associated with poor response to standard of care therapy for patients with platinum-resistant ovarian cancer, ER/PR+ HER2- breast cancer and EGFR wild-type non-small cell lung cancer. Heregulin-driven drug resistance pathways were found to be active in approximately 30-50% of patients tested. Results from three Phase 2 studies further showed that patients with heregulin-positive tumors experienced a statistically significant reduction in their risk of progression when they received a combination of MM-121 with their standard of care therapy as compared to patients who received the standard of care therapy alone. MM-121 is specifically designed to block heregulin binding to ErbB3. Top line data from these trials had previously been released. Detailed biomarker data for all three studies were presented at the American Society of Clinical Oncology Annual Meeting, May 30-June 3. Akos Czibere, MD, PhD, Senior Medical Director at Merrimack, said, "We look forward to advancing MM-121 into definitive studies that will allow us to prospectively screen patients for heregulin."
News For MACK From The Last 14 Days
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September 30, 2014
08:09 EDTMACKMerrimack presents additional Phase 2 biomarker data for MM-121
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September 26, 2014
10:10 EDTMACKMerrimack management to meet with Brean Capital
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05:40 EDTMACKPharmaEngine, Merrimack Pharmaceuticals amend MM-398 license agreement
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September 24, 2014
09:05 EDTMACKOn The Fly: Pre-market Movers
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07:39 EDTMACKMerrimack to hold a conference call
Conference call to discuss the exclusive license and collaboration agreement with Baxter International for the development and commercialization of MM-398 also known as "nal-IRI" will be held on September 24 at 8:30 am. Webcast Link
07:06 EDTMACKBaxter, Merrimack enter exclusive ex-U.S. licensing deal for MM-398
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