Eli Lilly's Cyramza for liver cancer did not meet Phase III primary endpoint Eli Lilly announced that the Phase III REACH trial of Cyramza in patients with hepatocellular carcinoma or liver cancer, did not meet its primary endpoint; overall survival favored the Cyramza arm but was not statistically significant. There were meaningful improvements in key secondary endpoints of progression-free survival, overall response rate and time to progression. The trial compared Cyramza plus best supportive care to placebo plus best supportive care as a second-line treatment in patients with hepatocellular carcinoma after being treated with sorafenib in the first-line setting. No Phase III study of liver cancer has been able to demonstrate improved survival in the second-line setting. Lilly plans to present data from the REACH trial at a scientific meeting later this year.