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June 13, 2014
05:17 EDTKPTIKaryopharm announces first combination data of Selinexor Phase 1 trial
Karyopharm Therapeutics announced initial Phase 1 data from patients with multiple myeloma treated with Karyopharm's lead selective inhibitor of nuclear export, or SINE, Selinexor, in combination with "low-dose" dexamethasone. Among eight patients, the best responses were one stringent complete response, or sCR, three partial responses, or PRs, two minor responses, or MRs, one progressive disease and one non-evaluable. Accordingly, the clinical benefit response rate is 75% and the overall response rate. Adverse events in patients receiving single-agent Selinexor were generally low-grade, consistent with events observed in patients with other hematological malignancies and responsive to standard supportive care. Compared with Selinexor given alone, fewer adverse events in patients receiving Selinexor in combination with dexamethasone were reported, consistent with dexamethasone's reduction in Selinexor's main side effects of nausea, anorexia, and fatigue.
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