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May 16, 2014
16:03 EDTKPTIKaryopharm treatment of acute myeloid leukemia granted orphan status
Selinexor from Karyopharm Therapeutics was granted FDA orphan designation in the treatment of acute myeloid leukemia, according to a post to the regulator's site. Reference Link
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April 13, 2015
08:43 EDTKPTIKaryopharm granted U.S. composition-of-matter patent for selinexor
Karyopharm Therapeutics announced the issuance of U.S. Patent No. 8,999,996 entitled "Hydrazide Containing Nuclear Transport Modulators and Uses Thereof." This patent, which will expire in 2032 absent any patent term extensions, covers the composition-of-matter of Karyopharm's lead product candidate, selinexor, a first-in-class, oral SINE compound, as well as certain other compositions and related methods. Selinexor is being evaluated in multiple registration-directed and other later stage trials in patients with relapsed and/or refractory hematological and solid tumor malignancies.

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