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News Breaks
May 22, 2014
07:06 EDTISISIsis Pharmaceuticals' ISIS-FXI shows positive Phase 2 data
Isis Pharmaceuticals announced positive top-line data from a Phase 2 comparator-controlled study evaluating the incidence of venous thrombolic events in patients treated with ISIS-FXIRx undergoing total knee replacement surgery, or total knee arthroplasty. ISIS-FXIRx inhibits the production of Factor XI, a coagulation factor that plays a key role in thrombosis. Patients treated with 300 mg of ISIS-FXIRx experienced a seven-fold lower incidence of VTEs compared to patients treated with enoxaparin. Patients treated with 200 mg of ISIS-FXIRx had comparable incidence of VTEs compared to patients treated with enoxaparin. .
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July 17, 2014
07:10 EDTISISIsis Pharmaceuticals begins Phase 2 study of candidate for high lipoprotein(a)
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July 16, 2014
07:14 EDTISISIsis Pharmaceuticals earns $1M milestone payment from GlaxoSmithKline
Isis Pharmaceuticals (ISIS) has earned a $1M milestone payment from GlaxoSmithKline (GSK) related to the advancement of the Phase 2/3 study of ISIS-TTRRx in patients with familial amyloid polyneuropathy. ISIS-TTRRx is an antisense drug in development with GSK for the treatment of transthyretin amyloidosis, a severe and rare genetic disease characterized by progressive dysfunction of peripheral nerve and/or heart tissues. Including this milestone payment, Isis has generated $27M in upfront and milestone payments for advancing ISIS-TTRRx. If GSK elects to exercise its option to exclusively license the ISIS-TTRRx program, Isis is eligible to receive a license fee, regulatory and sales milestone payments and double-digit royalties on sales of ISIS-TTRRx.

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