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June 1, 2014
16:46 EDTIMUCImmunoCellular presents updated ICT-107 Phase II data
ImmunoCellular Therapeutics announced that updated efficacy and safety data from the phase II trial of dendritic cell-based immunotherapeutic vaccine ICT-107 in patients with newly diagnosed glioblastoma multiforme, GBM, were presented at the 2014 American Society for Clinical Oncology, ASCO, annual meeting in Chicago. When overall survival. OS, and progression-free survival, PFS, were assessed in pre-specified patient subgroups, results favored treatment with ICT-107 over control in HLA-A2 patients within each of the two major MGMT subgroups. While the subgroups were small in size, and not powered to show statistical significance, the numeric advantages in favor of ICT-107 treated patients were shown to be large and clinically meaningful. HLA, human leukocyte antigens, are cell-surface antigen-presenting proteins. These molecules are on dendritic cells and present the tumor-associated antigens to T-cells to induce the immune response to the ICT-107 vaccine. HLA-A2 was one of two HLA types that were treated in the phase II trial. Of the two types, HLA-A2 is twice as common in the population as HLA-A1, and is the most common HLA type in North America and the EU.
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February 18, 2015
16:29 EDTIMUCImmunoCellular appoints Dr. Swanson to lead Stem-to-T-cell research program
ImmunoCellular Therapeutics announced the appointment of Steven Swanson, PhD, as SVP, Research. Dr. Swanson will lead the company's Stem-to-T-cell research program, which utilizes the patient's own hematopoietic stem cells to drive production of antigen-specific killer T-cells which then attack cancer cells. He will be responsible for all programmatic research and development, with the goal of identifying and advancing novel antigen-specific Stem-to-T-cell product candidates to the clinic. Prior to joining ImmunoCellular, Dr. Swanson was an independent consultant advising biopharmaceutical companies on basic immunology research, bioanalytical procedures, immunogenicity assessment, regulatory affairs and product quality.

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