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News Breaks
April 11, 2014
09:08 EDTICPTIntercept announces OCA preclinical study data
Intercept announced results from a preclinical study demonstrating the potential protective effects of obeticholic acid, or OCA, in an experimental model of liver disease. The study was presented orally during the opening session of the International Liver Congress 2014, the 49th Annual Meeting of the European Association for the Study of the Liver. The study has also been selected as the best oral abstract in Basic Science at ILC 2014. In the study, OCA administration was shown to have protective effects on bacterial translocation from the ileum in an experimental rat model of cholestasis. The six animals receiving OCA treatment experienced significant reduction of bacteria in mesenteric lymph nodes and all but one of these remained free from bacterial infection in the abdominal cavity. In contrast, all six animals in the control group developed an abdominal infection. OCA treatment was additionally associated with normalized intestinal permeability, along with reduced inflammation of the lymph nodes and spleen. This study is the first to show OCA treatment limits bacterial translocation from the small intestine. In patients with liver cirrhosis, this manifests as spontaneous bacterial peritonitis.
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July 14, 2014
10:00 EDTICPTOn The Fly: Analyst Initiation Summary
Today's noteworthy initiations include: Ardelyx (ARDX) initiated with a Buy at Citigroup... Century Communities (CCS) initiated with an Overweight at JPMorgan... Charles Schwab (SCHW) initiated with a Buy at Jefferies... Diamondback Energy (FANG) initiated with a Neutral at Sterne Agee... E-Trade (ETFC) initiated with a Hold at Jefferies... Foresight Energy (FELP) initiated with an Overweight at Morgan Stanley... Global Logistics Properties (GBTZF) initiated with an Overweight at Barclays... Intercept (ICPT) initiated with a Buy at Deutsche Bank... Jumei (JMEI) initiated with a Buy at BofA/Merrill... MTS Systems (MTSC) initiated with a Buy at Needham... Markit (MRKT) initiated with an Equal Weight at Morgan Stanley... Opus Bank (OPB) initiated with a Buy at CRT Capital... Parnell (PARN) initiated with an Overweight at Piper Jaffray... TD Ameritrade (AMTD) initiated with a Hold at Jefferies... Teradata (TDC) initiated with a Buy at Standpoint Research... Veritiv (VRTV) initiated with an Overweight at Barclays... Viper Energy (VNOM) initiated with a Market Perform at Raymond James... Yelp (YELP) initiated with an Underweight at Evercore... ZS Pharma (ZSPH) initiated with an Outperform at BMO Capital... Zafgen (ZFGN) initiated with an Outperform at Cowen.
06:02 EDTICPTIntercept initiated with a Buy at Deutsche Bank
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July 10, 2014
08:26 EDTICPTLeerink reiterates caution on Intercept ahead of FLINT data
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