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News Breaks
January 29, 2014
07:40 EDTGTXIGTx to present GTx-758 Phase 2 clinical trial preliminary findings
GTx announced that it will present preliminary findings from the company’s Phase 2 clinical trial evaluating GTx-758. The Phase 2 clinical trial is sequentially testing for safety and effectiveness of 125mg oral daily dose and 250mg oral daily dose of GTx-758 as secondary hormonal therapy in men with CRPC. The goal of the Phase 2 trial is to show that lower doses of GTx-758 are well tolerated and effective in reducing free testosterone and, in greater than 50% of subjects, achieving a 50% reduction of serum prostate specific antigen by Day 90. Preliminary data shows that a majority of subjects who were experiencing hot flashes prior to taking GTx-758 have reported improvement in and/or stabilization of their hot flashes and bone turnover biomarkers have decreased in a majority of the patients. As for safety, GTx-758 continues to be well tolerated, with no reported venous thromboembolic events or deaths.
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April 15, 2014
08:56 EDTGTXIGTx Chief Scientific Officer James Dalton resigns
GTx disclosed in a regulatory filing that James Dalton, Vice President, Chief Scientific Officer, notified the company of his decision to resign from his employment with GTx. Dalton is leaving GTx to become Dean of the University of Michigan College of Pharmacy. GTx currently expects to engage Dalton as a consultant to the company following his employment termination.
April 4, 2014
06:26 EDTGTXIGTx announces departure of CEO Mitchell Steiner
Steiner has also stepped down as Vice Chairman of the board effective April 3. Marc Hanover, the company's President and COO, has been named interim CEO.

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