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News Breaks
June 10, 2014
05:54 EDTGHDXGenomic Health announces results of three studies with Oncotype DX test
Genomic Health announced results of three studies with the Oncotype DX breast cancer test at the recent 2014 American Society of Clinical Oncology Annual Meeting. The PACS01 trial was a large study conducted in France which compared six cycles of fluorouracil, epirubicin, and cyclophosphamide with three cycles of FEC followed by three cycles of docetaxel in 1,999 node positive breast cancer patients. The study presented at ASCO2 included 530 patients from the original PACS01 trial and assessed the association of the Oncotype DX Recurrence Score results with distant recurrence in hormone-receptor-positive, node positive patients treated with either FEC or FEC-D. Results were consistent with those of a similar study3 conducted previously, and showed that the Recurrence Score was a significant predictor of distant recurrence and disease free survival in both treatment arms. Importantly, there was no indication that patients with low Recurrence Score results benefited from the addition of docetaxel to their treatment regimen. A comparison study evaluated if the information provided by Oncotype DX and the Risk of Recurrence scores are equivalent. Specifically, results in 52 node negative, estrogen receptor-positive, post-menopausal, tamoxifen-treated invasive breast cancer patients revealed a very low concordance between Oncotype DX and ROR results. Results of a large, positive study6 confirm that the Oncotype DX Recurrence Score results and quantitative ER expression predict late distant recurrence risk in certain early-stage invasive breast cancer patients after initial tamoxifen therapy. These results suggest that the Oncotype DX test may help identify which patients have greater potential to benefit from extended hormonal treatment beyond five years. The results suggest that extending tamoxifen beyond five years may be most beneficial in patients with high and intermediate Recurrence Score results with higher quantitative ER expression. Conversely, patients with low Recurrence Score results would be expected to have limited benefit from extended tamoxifen beyond five years due to much lower risk for late distant recurrence.
News For GHDX From The Last 14 Days
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August 28, 2015
10:02 EDTGHDXOn The Fly: Analyst Upgrade Summary
Today's noteworthy upgrades include: ADP (ADP) upgraded to Outperform from Market Perform at William Blair... ASML (ASML) upgraded to Buy from Hold at Berenberg... Abercrombie & Fitch (ANF) upgraded on Hollister fundamentals at RBC Capital... Akamai (AKAM) upgraded to Outperform from Market Perform at JMP Securities... Ares Capital (ARCC) upgraded to Outperform from Market Perform at Raymond James... Banco Santander (SAN) upgraded on valuation at Deutsche Bank... CIBC (CM) upgraded to Neutral from Underperform at Credit Suisse... Canon (CAJ) upgraded to Hold from Sell at Deutsche Bank... Citi (C) upgraded to Buy from Neutral at Guggenheim... Ctrip.com (CTRP) upgraded to Buy from Hold at Stifel... El Pollo Loco (LOCO) upgraded at Stifel... Genomic Health (GHDX) upgraded to Market Perform from Underperform at Raymond James... Golar LNG (GLNG) upgraded on valuation, upcoming project completion at Stifel... Habit Restaurants (HABT) upgraded to Buy from Hold at Stifel... Helmerich & Payne (HP) upgraded to Overweight from Equal Weight at Stephens... Himax (HIMX) upgraded to Outperform from Neutral at Credit Suisse... Huntington Bancshares (HBAN) upgraded to Buy from Neutral at Guggenheim... InterContinental (IHG) upgraded to Outperform from Neutral at Credit Suisse... Knight Transportation (KNX) upgraded to Strong Buy on valuation at Raymond James... LogMeln (LOGM) upgraded to Overweight from Sector Weight at Pacific Crest... Patterson Companies (PDCO) upgraded to Overweight from Neutral at Piper Jaffray... Qunar (QUNR) upgraded on valuation, positive catalysts at Stifel... Regions Financial (RF) upgraded to Buy from Neutral at Guggenheim... Ryder (R) upgraded to Strong Buy from Outperform at Raymond James... SVB Financial (SIVB) upgraded to Buy from Neutral at DA Davidson... Seagate (STX) upgraded to Buy from Hold at Cross Research... Sinopec (SNP) upgraded to Neutral from Sell at Citi... Summit Hotel Properties (INN) upgraded to Outperform at Baird... Texas Capital (TCBI) upgraded to Buy from Neutral at DA Davidson... The Medicines Co. (MDCO) upgraded to Buy from Hold at Jefferies... U.S. Bancorp (USB) upgraded to Buy from Neutral at Guggenheim... Weatherford (WFT) upgraded to Overweight from Equal Weight at Stephens.
06:11 EDTGHDXGenomic Health upgraded to Market Perform from Underperform at Raymond James
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August 24, 2015
08:29 EDTGHDXWilliam Blair to hold a field trip
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August 17, 2015
08:05 EDTGHDXGenomic Health's Oncotype DX prostate cancer test receives medicare coverage
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