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February 21, 2014
08:14 EDTEPZMEpizyme announces publication of preclinical data for EPZ-6438
Epizyme announced the publication of data from preclinical studies of the company's clinical candidate EPZ-6438, a potent and selective small-molecule inhibitor of EZH2, a histone methyltransferase. Oncogenic mutations in EZH2 occur in a subset of patients with non-Hodgkin lymphoma, implicating EZH2 as a therapeutic target in these patients. Detailed characterization of the correlation between EZH2 inhibition, methylation of the EZH2 target (H3K27), reversal of lymphomagenic gene expression and antiproliferative effects specific to EZH2 mutant-bearing NHL cell lines. Sustained tumor growth inhibition in animal models of EZH2 mutant-bearing NHL, including durable effects after drug dosing is discontinued.
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October 23, 2014
08:30 EDTEPZMEpizyme announces notice of allowance for U.S. patent applications
Epizyme announced that the US Patent and Trademark Office has granted Notices of Allowance for US Patent Applications, Nos. 14/136,551 and 14/136,738, both entitled “PRMT5 Inhibitors and Uses Thereof.” The allowed claims cover inhibitors of PRMT5 and methods of cancer treatment with PRMT5 inhibitors. PRMT5 is implicated in several cancers, including blood cancers. Epizyme also announced the publication of 10 patent applications covering chemical matter targeting several additional HMTs: CARM1, PRMT1, PRMT3, PRMT6 and PRMT8. These additional HMT targets are implicated in a variety of solid tumors and hematologic malignancies.
October 17, 2014
08:05 EDTEPZMEpizyme presents EPZ-6438 pre-clinical data
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