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May 5, 2014
07:17 EDTCYCCCyclacel Pharmaceuticals issued new Japanese patent
Cyclacel Pharmaceuticals announced that the Japanese Patent and Trademark Office issued two patents broadening the exclusivity of sapacitabine, the company's lead clinical candidate. Japanese Patent 5443763 claims novel pharmaceutical formulations of sapacitabine. Japanese Patent 5457196 claims methods of treating cancer comprising sapacitabine in combination with histone deacetylase inhibitors. Equivalent patents have been granted in the United States and other countries.
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September 18, 2014
07:06 EDTCYCCCyclacel Pharmaceuticals CYC065 data shows selectivity, activity
Cyclacel Pharmaceuticals announced the presentation of preclinical data demonstrating the therapeutic potential of CYC065, Cyclacel's second-generation cyclin dependent kinase, or CDK, inhibitor, to treat acute leukemias, and in particular those with rearrangements in the mixed lineage leukemia, or MLL, gene. The data showed that in vitro all human acute myelogenous leukemia, or AML, and acute lymphocytic leukemia, or ALL, cell lines with MLL rearrangements, or MLLr, tested were sensitive to CYC065 and that the drug inhibited MLL-driven gene expression. Potent anticancer activity of CYC065 was demonstrated in vivo in AML xenograft models resulting in over 90% inhibition of tumor growth. The data were presented at the 2014 Society of Hematologic Oncology meeting taking place September 17-20, 2014 in Houston, Texas.

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