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January 24, 2013
07:16 EDTCRISCuris doeses first patient in Phase 1 trial of Dual PI3 Kinase, CUDC-907
Curis announced that the first patient has been treated in a Phase I clinical study of CUDC-907 in patients with relapsed or refractory lymphoma or multiple myeloma. CUDC-907 is an orally-administered first-in-class small molecule drug candidate that has been designed as a dual inhibitor of phosphatidylinositol-3-kinase and histone deacetylase. As a result of this clinical advance, Curis is entitled to receive an additional $350,000 in milestone payments under the terms of its agreement with The Leukemia and Lymphoma Society.
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April 8, 2014
07:22 EDTCRISBiotech Industry Organization to hold a conference
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April 7, 2014
16:14 EDTCRISCuris reports CUDC-907, CUDC-427 data
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16:11 EDTCRISCuris, Debiopharm Group report preclinical data for Debio 0932
Curis and Debiopharm Group announced the presentation of data for Debio 0932 at the Annual Meeting of the American Association for Cancer Research, or AACR, that demonstrated synergy between Debio 0932 and various standard of care, or SOC, agents in multiple in vitro and xenograft models of non-small cell lung cancer, or NSCLC, and renal cell carcinoma, or RCC. Debio 0932 is currently being investigated in a Phase 1/2 trial in combination with SOC agents in patients with advanced NSCLC and in a Phase 1 trial in combination with everolimus, a mTOR inhibitor, in advanced RCC patients. In a high throughput combination screen performed with six different human NSCLC cell lines, Debio 0932 demonstrated consistent synergy with microtubule and mTOR/ Akt targeting agents across all six cell lines. Additionally, Debio 0932 also showed strong synergy with everolimus in multiple patient derived and conventional RCC cell lines. Similar synergy and anti-tumor activity with Debio 0932 in combination with these agents was also demonstrated in human xenograft models of NSCLC and RCC.

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