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August 12, 2014
18:07 EDTCLDNCelladon 4M share Secondary priced at $9.50
Credit Suisse and Jefferies acted as joint book running managers for the offering.
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October 27, 2014
07:12 EDTCLDNCelladon announces publication of data from mSCF gene therapy product
Celladon announced together with researchers at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai, the results of pre-clinical work on the membrane-bound form of the Stem Cell Factor, or mSCF, gene therapy product candidate in the September 2014 online issue of Circulation Heart Failure. The paper is entitled "Stem Cell Factor Gene Therapy Improves Cardiac Function after Myocardial Infarction in Swine". Stem cell factor, or SCF, is a ligand of the c-kit receptor, and is a critical cytokine which contributes to cell migration, proliferation, and survival. It has been shown that SCF expression naturally increases after myocardial infarction, or MI, and may be involved in cardiac repair. The aim of this study was to determine whether mSCF gene therapy improves cardiac function in a large animal model of MI-induced heart failure. The study demonstrated clear therapeutic efficacy in the animal model, where mSCF gene therapy, delivered at the ischemic border area in the heart, improved cardiac function, decreased cardiac cell death, and increased the density of blood vessels in the heart for up to three months post-treatment. These results extend the previously reported efficacy data of stem cell factor treatment in rodents to a more clinically relevant model, supporting the potential translation of this gene therapy approach to a functional cardiac regenerative therapy.

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