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Stock Market & Financial Investment News

News Breaks
April 10, 2014
10:49 EDTCERUCerulean 8.5M share IPO priced at $7
04/10/14--The deal size was raised to 8.5M from 5M shares and priced below the $11-$13 range. Leerink acted as lead book running manager for the offering.
News For CERU From The Last 14 Days
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April 13, 2015
07:11 EDTCERUCerulean says publication shows CRLX101 targets breast cancer stem cells
Cerulean Pharma announced the publication of a manuscript in Breast Cancer Research and Treatment, describing preclinical data that demonstrate CRLX101, Cerulean’s lead proprietary investigational drug, targets breast cancer stem cells and impedes resistance to anti-angiogenic therapy in breast cancer mouse models. The results of the study demonstrate that CRLX101, a dual topoisomerase-1 and HIF-1α inhibitor, blocks the HIF-1α mediated increase in cancer stem cells induced by Avastin in a triple-negative breast cancer xenograft mouse model. The up-regulation of HIF-1α by Avastin is believed to be a mechanism of resistance to anti-angiogenic therapy. The combined effects of CRLX101 plus Avastin on cancer stem cells and bulk tumor cells resulted in significant tumor shrinkage and delayed recurrence in this model. The manuscript posits that these data provide a compelling rationale for combining CRLX101 with angiogenic agents in patients with cancer where HIF-1α mediated increases in cancer stem cells may play a role in chemoresistance. The article, “CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to anti-angiogenic therapy in mouse models of breast cancer” by Conley, et al, was published in the April 2015 issue of Breast Cancer Research and Treatment.
April 7, 2015
06:07 EDTCERUCerulean 5.8M share Secondary priced at $6.00
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April 6, 2015
06:20 EDTCERUCerulean files to sell $35M in common stock
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