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December 11, 2012
05:08 EDTCELGCelgene's Revlimid and Vidazar combination therapy results presented at ASH
Celgene International Sarl announced that results from a study evaluating the combination of Revlimid plus Vidazar in patients 60 years or older with untreated acute myeloid leukemia, or AML, were presented at the American Society of Hematology, or ASH, annual meeting in Atlanta, GA. In the phase II investigator-initiated study, patients received Vidazar 75 mg/m2/day, days 1-7 followed by Revlimid 50 mg/day, days 8-28 of 42-day cycles. Treatment was continued until disease progression, unacceptable adverse event or completion of 12 cycles. With 42 patients enrolled in the study, the overall response rate was 41%, with 28% of patients achieving a complete response. Most common adverse events were grade 1-2 and gastrointestinal in nature. There was one case each of grade 3 fever, sepsis, hyponatremia, pneumonitis and SIRS syndrome.
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