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June 2, 2014
05:49 EDTCCXIChemoCentryx CCX168 shows improvement in BVAS
ChemoCentryx reported additional Phase II data related to CCX168, an orally administered inhibitor that targets the receptor for the complement protein known as C5a, or C5aR. Data from the first two steps of the CLEAR trial show that patients receiving CCX168 showed improvements in the Birmingham Vasculitis Activity Score, or BVAS, an overall disease activity index, including efficacy observed in both the renal and the non-renal components of the BVAS. BVAS response at 12 weeks was higher in patients on CCX168 than those patients receiving the standard of care. BVAS remission (a higher threshold that is thought to require 24 weeks of treatment or longer for maximum effect) at 12 weeks was comparable to standard of care. Both non-renal and renal disease components of BVAS were improved in patients on CCX168 treatment. Additionally, as previously reported, patients treated with CCX168 as compared to standard of care showed greater improvements in renal function based on renal disease activity measurements including estimated glomerular filtration rate, urinary albumin:creatinine ratio, and urinary monocyte chemoattractant protein-1:creatinine ratio.
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