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Stock Market & Financial Investment News

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June 2, 2014
04:55 EDTBOTA, BOTA, BOTA, BOTA, IMGN, IMGN, IMGN, IMGN, ARRY, ARRY, ARRY, ARRY, OFIX, OFIX, OFIX, OFIX, CMN, CMN, CMN, CMN, MDCO, MDCO, MDCO, MDCO, TTHI, TTHI, TTHI, TTHI, INO, INO, INO, INO, CNAT, CNAT, CNAT, CNAT, Q, Q, Q, QJefferies to hold a conference
2014 Global Healthcare Conference to be held in New York on June 2-5.
News For BOTA;CNAT;INO;TTHI;MDCO;CMN;OFIX;ARRY;IMGN;Q From The Last 14 Days
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March 27, 2015
06:08 EDTMDCOThe Medicines Co. assumed with a Neutral at Citigroup
Target $30.
March 26, 2015
15:16 EDTCNATConatus price target raised to $9 from $6 at Piper Jaffray
10:04 EDTQOn The Fly: Analyst Downgrade Summary
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09:23 EDTCNATOn The Fly: Pre-market Movers
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07:23 EDTQQuintiles downgraded at SunTrust
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07:15 EDTCNATConatus says NAFLD/NASH Emricasan trial met primary endpoint
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06:04 EDTTTHITransition Therapeutics announces results from two Phase 1 studies of ELND005
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06:03 EDTTTHITransition Therapeutics announces results from Phase 1 AME study of ELND005
Transition Therapeutic announced results from two phase 1 clinical studies of neuropsychiatric drug candidate ELND005. These studies, an absorption-metabolism-excretion study and a renal clearance study, are specialized clinical pharmacology trials that are required by the FDA for the approval of most drugs in development. The AME study enrolled 8 subjects and the renal clearance study enrolled 42 subjects. In both studies, ELND005 showed good safety and tolerability. The key result of the AME study was that ELND005 showed good oral bioavailability as there was nearly 100% absorption. ELND005 showed no evidence of hepatic or intermediary metabolism and the study demonstrated that the main excretion route of ELND005 is via the kidney. These AME properties of good oral bioavailability, low protein binding, and lack of CYP metabolism are usually associated with consistent plasma levels and with a reduced risk of drug-drug interactions. The AME profile of ELND005 is well suited for an Alzheimer's disease patient population that is commonly administered multiple concomitant medications, many of which are metabolized by the liver. The renal clearance study evaluated the pharmacokinetic profile of ELND005 in subjects with various degrees of renal impairment. In this study, ELND005 showed minimal protein binding in plasma regardless of renal function. Across the 5 study arms, subjects with worse renal function had increased plasma drug exposure compared to those with normal renal function. The study provided important guidance for the minimum creatinine clearance needed to allow patient participation in studies with a fixed dose regimen of ELND005. This minimum creatinine clearance is consistent with the threshold used as exclusion criterion in the ongoing study of ELND005 in Agitation and Aggression of AD.
05:51 EDTQQuintiles downgraded to Neutral from Buy at SunTrust
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March 25, 2015
07:16 EDTINO, QPiper Jaffray and the Alliance for Regenerative Medicine co-host conference
3rd Annual Regenerative Medicine Investor Day is being held in New York on March 25 with webcasted company presentations to begin at 8 am; not all company presentations may be webcasted. Webcast Link
07:12 EDTMDCOAmerican Academy of Orthopedic Surgeons to hold annual meeting
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March 23, 2015
16:20 EDTIMGNOn The Fly: Closing Wrap
Stocks on Wall Street opened in relatively quiet fashion and remained that way throughout the session until a sharp selloff in the closing minutes. For most of the day the averages moved in a narrow range, as the Dow broke its streak of consecutive days with triple digit moves. Like stocks, the oil markets had a quiet session that stood out amid the recent volatility in crude prices. A late day drop prevented the major stock indexes from adding to the big gains they'd notched on Friday. ECONOMIC EVENTS: In the U.S., the Chicago Fed's national activity index fell to -0.11 in February, below expectations for a reading of 0.10. Existing home sales rose 1.2% to a 4.88M rate in February, which was below the consensus forecast for them to grow 2% to a 4.92M unit rate. COMPANY NEWS: Shares of Kansas City Southern (KSU) declined $9.21, or 7.96%, to $106.48 after the railroad operator lowered its fiscal year revenue guidance to reflect slower year-to-date carload growth primarily from the energy sector, along with a continued deterioration in the value of the Mexican peso against the U.S. dollar and lower fuel surcharge revenues driven by lower WTI prices. The revenue warning appeared to weigh on others in the rail industry as well, with Union Pacific (UNP) falling $4.67, or 3.98%, to $112.78, Norfolk Southern (NSC) dropping $3.87, or 3.5%, to $106.56 and Canadian National (CNI) sliding $1.13, or 1.65%, to $67.24. MAJOR MOVERS: Among the notable gainers was ImmunoGen (IMGN), which gained $1.25, or 16.8%, to $8.69 after Takeda (TKPYY) licensed rights to use the company's antibody drug conjugate technology. Also higher was Tenet Healthcare (THC), which rose $2.45, or 4.94%, to $52.07 after agreeing to combine its short-stay surgery and imaging center assets into a new joint venture with United Surgical Partners International. Tenet will initially own 50.1% of the joint venture and will consolidate its financial results and will have a path to full ownership of USPI over the next five years through a put/call structure, the company noted. Among the noteworthy losers was MEI Pharma (MEIP), which plunged $4.37, or 69.37%, to $1.93 and was downgraded by at least four Wall Street research firms after the combination of Pracinostat and azacitidine showed no difference in the rate of complete remission, the primary endpoint of a Phase II study, compared to azacitidine alone. Also lower were shares of Vertex (VRTX), which fell $5.21, or 3.98%, to $125.79 after reporting data from a study evaluating VX-661 in combination with ivacaftor in cystic fibrosis that JPMorgan said was generally below expectations. INDEXES: The Dow fell 11.61, or 0.06%, to 18,116.04, the Nasdaq lost 15.44, or 0.31%, to 5,010.97, and the S&P 500 dropped 3.68, or 0.17%, to 2,104.42.
16:05 EDTCNATConatus, Sigma-Aldrich present Emricasan preclinical safety results
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12:17 EDTIMGNOn The Fly: Midday Wrap
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09:28 EDTIMGNOn The Fly: Pre-market Movers
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06:53 EDTINOInovio to host investor day
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06:31 EDTIMGNTakeda licenses rights to use ImmunoGen's antibody drug conjugate technology
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March 20, 2015
11:41 EDTCMNCantel Medical names Peter Clifford as CFO
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10:00 EDTMDCOOn The Fly: Analyst Initiation Summary
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March 19, 2015
16:06 EDTMDCOThe Medicines Co. initiated with a Neutral at Mizuho
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