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March 13, 2014
12:37 EDTAZNAstraZeneca downgraded to Underweight from Neutral at JPMorgan
News For AZN From The Last 14 Days
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September 4, 2015
10:35 EDTAZNFly Watch: Clovis, AstraZeneca to present data at lung cancer conference
AstraZeneca (AZN), Clovis Oncology (CLVS), OncoMed (OMED) and Verastem (VSTM) are companies likely to be impacted by their presentations at the World Conference on Lung Cancer, which is set to begin this weekend, said research firm Mizuho Securities. WHAT'S NEW: AstraZeneca will present data on its '9291 drug for non-small cell lung cancer and discuss the drug's effect on pre-treated patients at the conference, which is being held September 6- September 9, Mizuho analyst Phil Lawson pointed out in a note to investors today. AstraZeneca's presentations on '9291 could pressure Clovis Oncology, which has its own non-small cell lung cancer treatment, rociletinib, the analyst stated. Meanwhile, data on rociletinib could indicate that the drug could be prescribed to more patients and that it can be used to treat patients with earlier stages of the disease, Lawson believes. Verastem will report data on the efficacy of its defactinib drug as a treatment for non-small cell lung cancer with a mutation called KRAS, which involves an amino acid. Defactinib targets cancer stem cells. According to Lawson, there was previously an overreaction to the deaths of two patients who were taking the drug and he will be closely examining the safety data on the drug as well. Oncomed, which also seeks to target cancer stem cells, will present updated data for its tarextumab drug in small cell lung cancer and should present more mature efficacy data, the analyst stated. PRICE ACTION: In early trading in a down day for the broader market, AstraZeneca slid 0.9% to $32, Clovis added 1.8% to $82.84, Oncomed was up 0.2% to $18.72 and Verastem gained 2.5% to $6.
08:02 EDTAZNAstraZeneca to give data on lung cancer portfolio at WCLC 2015
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07:57 EDTAZNAstraZeneca has a conference call hosted by JPMorgan
JPMorgan Analyst Gordon will host a conference call with CEO Pascal Soriot on September 9 at 10 am.
September 3, 2015
17:57 EDTAZNAstraZeneca confirms FDA approval of Brilinta tablets
AstraZeneca confirmed that the FDA has approved Brilinta tablets at a new 60mg dose to be used in patients with a history of heart attack beyond the first year. With this expanded indication, Brilinta is now approved to reduce the rate of cardiovascular death, myocardial infarction, or MI also known as heart attack, and stroke in patients with acute coronary syndrome, or ACS, or a history of MI. Brilinta is an oral antiplatelet treatment that works by inhibiting platelet activation and was first approved by the FDA in July 2011 on the basis of data from the PLATO study. For at least the first 12 months following ACS, it is superior to clopidogrel and is the first and only FDA approved oral antiplatelet to demonstrate superior reductions in CV death vs clopidogrel. Brilinta also reduces the rate of stent thrombosis in patients who have been stented for the treatment of ACS. In the management of ACS, the recommended maintenance dose of Brilinta is 90mg twice daily during the first year after an ACS event. After one year, patients with a history of heart attack can now be treated with 60mg twice daily. Brilinta should be used with a daily maintenance dose of aspirin of 75-100mg.
17:27 EDTAZNAstraZeneca: FDA approves expanded indication for BRILINTA
AstraZeneca announced that the U.S. FDA has approved BRILINTA tablets at a new 60mg dose to be used in patients with a history of heart attack beyond the first year. With this expanded indication, BRILINTA is now approved to reduce the rate of cardiovascular death, myocardial infarction and stroke in patients with acute coronary syndrome or a history of MI. The new BRILINTA 60mg tablet is expected to be available in pharmacies by the end of September 2015. Reference Link
September 2, 2015
10:00 EDTAZNOn The Fly: Analyst Upgrade Summary
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06:41 EDTAZNAstraZeneca upgraded to Buy from Hold at HSBC
HSBC upgraded AstraZeneca to Buy based on recent shares weakness and a large amount of Oncology and ImmunoOncology news flow in the coming months.
September 1, 2015
08:33 EDTAZNNektar receives $40M milestone payment from first commercial sale of Moventig
Nektar (NKTR) announced that it has received a $40M cash payment under a license agreement with AstraZeneca (AZN). The payment was triggered by the first commercial sale of MOVENTIG (naloxegol) in Germany. MOVENTIG is the first once-daily, oral peripherally-acting mu-opioid receptor antagonist (PAMORA) medication approved in the European Union for the treatment of opioid-induced constipation (OIC) in adult patients who have had an inadequate response to laxatives. MOVENTIG is marketed in the U.S. by AstraZeneca as MOVANTIK and is the first once-daily oral PAMORA medication indicated for the treatment of OIC in adult patients with chronic, non-cancer pain. MOVENTIG/MOVANTIK is part of the exclusive worldwide license agreement announced on September 21, 2009 between AstraZeneca and Nektar Therapeutics. Under the terms of the agreement, in addition to the $40 million milestone payment announced today, Nektar received a $100 million milestone payment upon first commercial sale of MOVANTIK in the U.S. in March of 2015. Nektar is also entitled to royalties on worldwide net product sales and up to $375 million in sales milestones. The royalty rate in the U.S. starts at 20% and escalates. The royalty rate in Europe and the rest of the world starts at 18% and escalates. Under the agreement, AstraZeneca is responsible for all sales and marketing activities for MOVANTIK worldwide.
05:33 EDTAZNValeant, AstraZeneca to partner on brodalumab
Valeant Pharmaceuticals (VRX) announced that its affiliate has entered into a collaboration agreement with AstraZeneca (AZN) under which Valeant was granted an exclusive license to develop and commercialize brodalumab. Brodalumab is an IL-17 receptor monoclonal antibody in development for patients with moderate-to-severe plaque psoriasis and psoriatic arthritis. Under the agreement, Valeant will hold the exclusive rights to develop and commercialize brodalumab globally, except in Japan and certain other Asian countries where rights are held by Kyowa Hakko Kirin under a prior arrangement with Amgen Inc., the originator of brodalumab. Valeant will assume all development costs associated with the regulatory approval for brodalumab. Regulatory submission in U.S. and EU for brodalumab in moderate-to-severe psoriasis is planned for Q4. Under the terms of the agreement, Valeant will make an up-front payment to AstraZeneca of $100M, as well as additional pre-launch milestones of up to $170M and further sales-related milestone payments of up to $175M following launch. After approval, AstraZeneca and Valeant will share profits.
August 27, 2015
07:51 EDTAZNRoche catching up fast to Bristol-Myers in immuno-oncology, says Jefferies
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August 24, 2015
05:13 EDTAZNAstraZeneca to collaborate with Peregrine on cancer immunotherapy clinical trial
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August 23, 2015
12:35 EDTAZNBiotech firms could see 'billions' in sales from new cancer drugs, Barron's says
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