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Stock Market & Financial Investment News

News Breaks
March 26, 2013
10:04 EDTZIOP, MGLN, COG, SWN, MWV, ASH, TWO, KRA, GMANOn The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: Ashland (ASH) downgraded to Neutral from Buy at Longbow... Cabot Oil & Gas (COG) downgraded to Hold from Buy at Stifel... Gordmans Stores (GMAN) downgraded to Neutral from Overweight at Piper Jaffray... Kraton Performance (KRA) downgraded to Perform from Outperform at Oppenheimer... Magellan Health (MGLN) downgraded to Market Perform from Outperform at Raymond James... MeadWestvaco (MWV) downgraded to Neutral from Buy at UBS... Southwestern Energy (SWN) downgraded to Hold from Buy at Stifel... Ziopharm (ZIOP) downgraded to Underperform from Market Perform at BMO Capital... Two Harbors (TWO) downgraded to Neutral from Buy at Compass Point... Cabot Oil & Gas (COG) downgraded to Hold from Buy at Stifel... Southwestern Energy (SWN) downgraded at Stifel.
News For ASH;COG;GMAN;MWV;MGLN;KRA;SWN;ZIOP;TWO From The Last 14 Days
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September 1, 2015
08:08 EDTZIOPZiopharm announces publication of study in Cancer Research
ZIOPHARM Oncology announced the publication of a preclinical study in Cancer Research, a journal of the American Association for Cancer Research, demonstrating the preferential targeting of solid tumor cells over healthy cells using engineered chimeric antigen receptor, or CAR, T cells. The article, titled "Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent anti-tumor activity," is available online first at cancerres.aacrjournals.org, and was highlighted in a press release today by AACR. Abnormally-expressed antigens on tumors, such as epidermal growth factor receptor, or EGFR, on aggressive brain tumors such as glioblastoma, can be overexpressed relative to lower, basal levels on normal tissues. Taking advantage of this observation, researchers at The University of Texas MD Anderson Cancer Center tuned the binding affinity of CARs to activate T cells based on the density of EGFR expression. The approach was based on the clinical toxicity exhibited by the EGFR-specific antibodies cetuximab and nimotuzumab, which recognize overlapping epitopes and exhibit different kinetics of binding to EGFR. The lower affinity of nimotuzumab has been credited with absence of adverse events relative to cetuximab. Researchers engineered high-affinity cetux-CAR T cells and low-affinity nimo-CAR T cells, which were tested in vitro on cancer cells with high levels of EGFR, and normal cells with low levels of EGFR. It was found that, while the cetux-CAR T cells killed both cancer and normal cells, the nimo-CAR T cells were selectively activated only in response to cancer cells. The researchers then tested the two populations of genetically modified T cells in mice bearing human brain cancer cells expressing high levels of EGFR and found that both cetux- and nimo-CAR T cells were equally effective in inhibiting tumor growth. However, the cetux-CAR T cells caused significant toxicity to the mice, leading to death in some, whereas the infused nimo-CAR T cells were found to be safe. The researchers further tested both CAR T cells in mice bearing cells that had low levels of EGFR, and found that unlike cetux-CAR T cells, the nimo-CAR T cells did not impact the growth of these cells.
August 31, 2015
09:31 EDTSWNSouthwestern Energy management to meet with UBS
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August 28, 2015
12:01 EDTSWNStocks with call strike movement; CHK SWN
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August 27, 2015
10:00 EDTSWNOn The Fly: Analyst Initiation Summary
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06:29 EDTSWNSouthwestern Energy at Wellington Shields
August 25, 2015
17:17 EDTKRAKraton Performance files automatic mixed securities shelf
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August 24, 2015
16:23 EDTCOGOn The Fly: Top stock stories for Monday
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August 21, 2015
08:05 EDTZIOPZiopharm discloses that it entered into a R&D agreement with MD Anderson
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08:03 EDTGMANGordmans Stores sees Q3 EPS (15c)-(12c), consensus (10c)
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08:02 EDTGMANGordmans Stores reports Q2 adjusted EPS (9c), consensus (14c)
Reports Q2 revenue $143.4M, consensus $145.45M.

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