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Stock Market & Financial Investment News

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February 28, 2014
06:07 EDTMNKD, ARIAStocks with implied volatility movement; MNKD ARIA
Stocks with implied volatility movement; MannKind (MNKD) 188, ARIAD (ARIA) 87 according to iVolatility.
News For ARIA;MNKD From The Last 14 Days
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April 24, 2015
05:47 EDTMNKDStocks with implied volatility movement; EWT MNKD
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April 22, 2015
07:38 EDTARIAARIAD issued U.S. patent on brigatinib
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05:58 EDTMNKDStocks with implied volatility above IV index mean; MNKD GMCR
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April 21, 2015
14:30 EDTARIAARIAD could be worth double current value to strategic buyer, BBJ BioFlash says
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07:36 EDTARIAARIAD anounces results of preclinical studies on Brigatinib at AACR meeting
ARIAD Pharmaceuticals announced the results of a series of preclinical studies on its investigational tyrosine kinase inhibitor, brigatinib at the American Association for Cancer Research Annual Meeting 2015. Brigatinib is in development for the treatment of patients with anaplastic lymphoma kinase positive metastatic non-small cell lung cancer, who are resistant to crizotinib. An oral presentation describes, for the first time, the design and chemical structure of brigatinib, discovered using ARIADís structure-based drug design platform. With the goal of designing a selective ALK inhibitor with broad-based activity against crizotinib-resistant mutants, ARIAD scientists advanced a series of novel compounds culminating in the identification of brigatinib. Brigatinib incorporates unique chemical-design features, including the distinctive use of a recognition element that confers favorable pharmacologic properties. Brigatinib has at least 10-fold greater potency than crizotinib against ALK+ NSCLC cell lines and was broadly active against clinically relevant crizotinib-resistant mutants in preclinical models. A poster presentation shows that brigatinib, at clinically achievable concentrations, has potent anti-tumor activity against a panel of 17 distinct ALK mutants known to confer resistance to other ALK inhibitors. In a separate study designed to model the occurrence of brain metastases in ALK+ lung cancer patients, brigatinib significantly reduced the tumor burden in mice with ALK+ brain tumors compared to the tumors in mice treated with crizotinib. Survival of brigatinib-treated mice was also markedly enhanced compared to the survival duration of crizotinib-treated mice.
06:03 EDTMNKDStocks with implied volatility above IV index mean; MNKD GMCR
Stocks with implied volatility above IV index mean; MannKind (MNKD) 75, Keurig Green Mountain (GMCR) 52 according to iVolatility.
April 20, 2015
07:20 EDTARIAAmerican Association for Cancer Research to hold annual meeting
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06:06 EDTMNKDStocks with implied volatility above IV index mean; MNKD GMCR
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April 17, 2015
07:36 EDTARIAARIAD presents updated clinical data on Brigatinib
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April 15, 2015
05:51 EDTMNKDStocks with implied volatility movement; ZIOP MNKD
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April 13, 2015
14:20 EDTARIANHS Scotland accepts ARIAD's Iclusig for use
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