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News Breaks
March 28, 2014
07:40 EDTARIA, JAZZARIAD volatility is expected to move on acquisition rumors reports
ARIAD (ARIA) volatility is expected to move on rumors suggest that Jazz Pharmaceuticals (JAZZ) is willing to pay $20-plus per share to acquire ARIAD, Daily Mail says. Overall option implied volatility of 81 is below its 26-week average of 100 according to Track Data, suggesting decreasing price movement.
News For ARIA;JAZZ From The Last 14 Days
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April 23, 2015
09:20 EDTJAZZCelgene patent latest to be challenged by Hayman Capital's Bass
The Coalition For Affordable Drugs, a group linked to Hayman Capital's Kyle Bass, has requested an Inter Partes Review of Claims 1–10 of U.S. Patent No. 6,045,501 held by Celgene (CELG), according to a USPTO filing. The ’501 patent claims methods for delivering a drug, including a teratogenic drug, to a patient while preventing the exposure of a fetus or other contraindicated individuals to the drug. The patent is related to the company's Revlimid drug. BACKGROUND: Previously, the same coalition requested an Inter Partes Review of patents held by Pharmacyclics (PCYC), Acorda Therapeutics (ACOR), Shire (SHPG) and Jazz Pharmaceuticals (JAZZ). On January 7, Reuters reported that Bass planned to take "around 15 pharmaceutical companies with a combined market capitalization of $450B" into an Inter Partes Review for extending patents in questionable ways, citing a presentation made by Bass in Oslo. PRICE ACTION: Shares of Celgene are down 0.5% to $114.92 in pre-market trading.
April 22, 2015
07:38 EDTARIAARIAD issued U.S. patent on brigatinib
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April 21, 2015
14:30 EDTARIAARIAD could be worth double current value to strategic buyer, BBJ BioFlash says
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07:36 EDTARIAARIAD anounces results of preclinical studies on Brigatinib at AACR meeting
ARIAD Pharmaceuticals announced the results of a series of preclinical studies on its investigational tyrosine kinase inhibitor, brigatinib at the American Association for Cancer Research Annual Meeting 2015. Brigatinib is in development for the treatment of patients with anaplastic lymphoma kinase positive metastatic non-small cell lung cancer, who are resistant to crizotinib. An oral presentation describes, for the first time, the design and chemical structure of brigatinib, discovered using ARIAD’s structure-based drug design platform. With the goal of designing a selective ALK inhibitor with broad-based activity against crizotinib-resistant mutants, ARIAD scientists advanced a series of novel compounds culminating in the identification of brigatinib. Brigatinib incorporates unique chemical-design features, including the distinctive use of a recognition element that confers favorable pharmacologic properties. Brigatinib has at least 10-fold greater potency than crizotinib against ALK+ NSCLC cell lines and was broadly active against clinically relevant crizotinib-resistant mutants in preclinical models. A poster presentation shows that brigatinib, at clinically achievable concentrations, has potent anti-tumor activity against a panel of 17 distinct ALK mutants known to confer resistance to other ALK inhibitors. In a separate study designed to model the occurrence of brain metastases in ALK+ lung cancer patients, brigatinib significantly reduced the tumor burden in mice with ALK+ brain tumors compared to the tumors in mice treated with crizotinib. Survival of brigatinib-treated mice was also markedly enhanced compared to the survival duration of crizotinib-treated mice.
April 20, 2015
14:32 EDTJAZZPharmacyclics patent for Imbruvica challenged by Hayman Capital's Bass
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07:20 EDTARIAAmerican Association for Cancer Research to hold annual meeting
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April 17, 2015
07:36 EDTARIAARIAD presents updated clinical data on Brigatinib
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April 13, 2015
14:20 EDTARIANHS Scotland accepts ARIAD's Iclusig for use
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