Ampio announces positive results from Ampion study Ampio Pharmaceuticals announced the one month results of the open label portion of the multiple injections of Ampion into the knees of patients with osteoarthritis, or OA. Company explained "This first part of the multiple injections study involved patients receiving a series of three 4ml injections of Ampion intra-articularly. In order to proceed with the randomized vehicle- controlled portion of the trial, we had to repeat a demonstration of both safety and efficacy even though efficacy and safety had been demonstrated previously in the single injection SPRING study. No serious drug related adverse events were reported in either trial. The WOMAC A pain score improved by 65% from baseline with the multiple injections at one month post injection compared to 33% in the SPRING study at the same time point. In addition, the function score WOMAC C compared to baseline improved by 74 % at 4 weeks. The study also includes serial high resolution MRI's at various time points that will explore whether there are clinical benefits beyond pain relief."