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October 3, 2013
08:12 EDTALNYAlnylam, collaborators publish ALN-PCS clinical trial results
Alnylam Pharmaceuticals announced the publication in The Lancet of complete study results from a Phase I trial with ALN-PCS. The paper reports the results of a study evaluating single intravenous dose administration of ALN-PCS, in the absence of concomitant lipid-lowering agents such as statins. Specifically, ALN-PCS administration resulted in a rapid, dose-dependent reduction in plasma PCSK9 of up to 84% relative to baseline and placebo, with a corresponding reduction in serum levels of low-density lipoprotein cholesterol, a clinically validated endpoint, of up to 57% relative to baseline and placebo. The knockdown of PCSK9 and lowering of LDL-C were also found to be durable, with effects lasting for weeks after a single dose. This new paper documents the first human proof of concept for an RNAi therapeutic impacting a clinically validated endpoint.
News For ALNY From The Last 14 Days
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April 24, 2015
09:32 EDTALNYJPMorgan Smid biotech analysts hold an analyst/industry conference call
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April 21, 2015
11:01 EDTALNYAlnylam price target raised to $145 from $125 at Leerink
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09:22 EDTALNYOn The Fly: Pre-market Movers
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06:59 EDTALNYAlnylam to host conference call
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06:03 EDTALNYAlnylam announces positive results from Phase 2 study with patisiran
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April 20, 2015
07:18 EDTALNYAmerican Academy of Neurology to hold annual meeting
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April 14, 2015
08:18 EDTALNYAlnylam data encouraging, says JMP Securities
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April 13, 2015
11:02 EDTALNYAlnylam publishes pre-clinical results on ALN-AT3
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10:15 EDTALNYHigh option volume stocks
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