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May 17, 2013
08:04 EDTALNYAlnylam announces proof-of-concept data from RNAi program
Alnylam announced that it has presented pre-clinical proof-of-concept data from its RNAi therapeutic program targeting aminolevulinate synthase-1 for the treatment of porphyria including acute intermittent porphyria. "The new research results support the advancement of RNAi therapeutics as a promising strategy for the prevention and/or treatment of acute attacks in patients with AIP," the company said. It added, "In particular, a prototype GalNAc-siRNA targeting ALAS-1 was shown to be effective in blocking ALA and PBG production in both prophylactic and treatment models of AIP. The company is on track to designate a GalNAc-siRNA development candidate, ALN-AS1, in late 2013 resulting in an investigational new drug (IND) filing in 2014."
News For ALNY From The Last 14 Days
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September 18, 2014
07:49 EDTALNYAlnylam resumed with an Outperform at Leerink
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September 16, 2014
08:02 EDTALNYAlnylam presents ALN-CC5 pre-clinical data
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September 15, 2014
08:01 EDTALNYAlnylam names Karen Anderson as SVP, Chief Human Resources Officer
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07:21 EDTALNYHeart Failure Society of America to hold annual meeting
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September 12, 2014
08:02 EDTALNYAlnylam broadens pipeline with ALN-AGT
Alnylam Pharmaceuticals announced that it is broadening its pipeline with ALN-AGT. In a poster presented at the American Heart Associationís High Blood Pressure Research 2014 Scientific Sessions, Alnylam and collaborators at the Charite Universitatsmedizin in Berlin presented results of an ALN-AGT lead molecule in an established preeclamptic rodent model. The study showed that administration of ALN-AGT resulted in knockdown of maternal AGT in the liver without detectable evidence of fetal drug exposure, significantly improved pregnancy-related hypertension, ameliorated preeclamptic sequelae in the mother such as proteinuria, and improved fetal outcomes.

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