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June 6, 2014
11:05 EDTRGP, CMLP, JNS, ALIM, IRWD, WYN, TPH, DMND, JE, BKDHigh option volume stocks
High option volume stocks: ALIM BKD TPH JNS JE WYN CMLP DMND IRWD RGP
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November 30, 2015
16:09 EDTIRWDIronwood, Astellas say Phase 3 linaclotide trial in Japan met primary endpoints
Astellas Pharma (ALPMY) and Ironwood Pharmaceuticals (IRWD) announced that the Phase 3 clinical trial of linaclotide conducted in Japan in adults with irritable bowel syndrome with constipation met its primary endpoints. Astellas expects to submit a new drug application to the Ministry of Health, Labor and Welfare in Japan in 2016, the company noted. Top-line data from the trial indicate linaclotide-treated patients showed "statistically significant" improvement compared to placebo-treated patients for both of the two co-primary endpoints. Regarding the first primary endpoint, 34% of linaclotide-treated patients were so-called Global Assessment of Relief of IBS Symptoms Responders, compared to 18% of placebo-treated patients. Regarding the second primary endpoint, 35% of linaclotide-treated patients were Complete Spontaneous Bowel Movement Overall Responders, compared to 19% of placebo-treated patients. Additionally, improvements were achieved in pre-specified secondary endpoints in the trial covering abdominal and constipation symptoms, including bloating and abdominal pain. Diarrhea rates in the trial were 9.6% for linaclotide versus 0.4% for placebo.
10:21 EDTWYNWyndham Vacation Rentals, announce distribution agreement, part of The Priceline Group (PCLN), and Wyndham Vacation Rentals, part of Wyndham Exchange & Rentals and the Wyndham Worldwide family of brands (WYN), have announced a new worldwide distribution agreement. Through this arrangement, Wyndham's global portfolio of vacation rental brands, including Landal GreenParks, NOVASOL, Hoseasons, and Wyndham Vacation Rentals North America, will now be able to utilize the website and mobile apps as distribution channels for their properties. Over the past two years, has worked individually with several brands of Wyndham Vacation Rentals, primarily in Europe. " has been a great partner for us in Europe, and we're very excited to extend our relationship globally through this new agreement," said Gail Mandel, president and CEO, Wyndham Exchange & Rentals, the parent company of Wyndham Vacation Rentals. Additional terms of the agreement have not been disclosed.
08:02 EDTIRWDIronwood says Phase II Linaclotide trial data 'positive'
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November 19, 2015
07:27 EDTWYNMKM Partners to hold a conference
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