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News Breaks | | | | February 27, 2013 | | 07:03 EDT |  | AGEN | Agenus' HerpV Phase 2 study to treat genital herpes completes enrollment
Agenus announced it has completed patient screening in its Phase 2 randomized, double-blind, multicenter study for HerpV, a recombinant "off-the-shelf" therapeutic vaccine candidate for the treatment of genital herpes in herpes simplex virus-2, or HSV-2, positive patients. HerpV contains Agenus' QS-21 Stimulon adjuvant. The Phase 2 study has screened over 100 HSV-2 positive subjects and enrollment has been closed. The study will test the biological efficacy of HerpV as measured by effect on genital viral shedding after three injections of the therapeutic vaccine. A booster injection of HerpV will be given at six months after treatment to evaluate the potential durability of treatment effect. The HerpV Phase 2 study has been supported by leading clinical experts in the field who have expressed that a reduction in viral shedding could translate into clinical benefit. A therapeutic vaccine to treat HSV-2 infected patients has the potential to provide a major paradigm shift in the treatment of this infection as well as provide significant quality of life benefits. | |
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| May 22, 2013 | | 07:09 EDT | | AGEN | Agenus begins enrollment in NCI-Sponsored randomized trial of Prophage G-200
Agenus announced enrollment has started for a large, randomized Phase 2 study of Prophage G-200 vaccine in combination with bevacizumab for treatment of recurrent glioblastoma multiforme in adult patients. The study is being sponsored by the Alliance for Clinical Trials in Oncology, a cooperative group of the National Cancer Institute. The trial is expected to enroll 222 patients in treatment centers across the United States, and is the largest brain tumor vaccine trial ever funded by NCI and the largest vaccine study ever conducted with Avastin. | |
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