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June 4, 2014
08:07 EDTADXSAdvaxis announces ADXS-HPV publication or preclinical research
Advaxis announced the publication of preclinical research with its lead candidate, ADXS-HPV for the treatment of HPV-associated cancers in the journal, Cancer Immunology Research. In this publication, researchers at the National Cancer Institute reported on the biologic mechanisms behind the unique ability of ADXS-HPV to decrease the immunosuppressive activity of Tregs in the tumor microenvironment that result in increased anti-tumor activity. This research demonstrates the critical role of the tLLO peptide fusion and the strong adjuvant effect of tLLO as contributing to the increase in activated T-cells and the relative decrease in the number of Tregs in tumors, thereby increasing anti-tumor activity. The company said, "The results are better than those achieved in earlier studies with different Lm-based immunotherapies. They suggest that tLLO serves as a promising adjuvant and that its incorporation into ADXS-HPV is a critical contributor to the changes in the tumor microenvironment that favor immune killing of the tumor cells." ADXS-HPV is in clinical trials for three HPV-associated cancers. Advaxis reported final Phase 2 data in recurrent cervical cancer at the 2014 American Society of Clinical Oncology Annual Meeting and plans to move forward with a registration program in recurrent cervical cancer.
News For ADXS From The Last 14 Days
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December 19, 2014
16:26 EDTADXSAdage Capital Partners reports 18.84% passive stake in Advaxis
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December 15, 2014
07:33 EDTADXSAdvaxis announces FDA acceptance of INDA to commence clinical trials of ADXS-HPV
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December 8, 2014
09:20 EDTADXSOn The Fly: Pre-market Movers
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07:35 EDTADXSAdvaxis reports FDA acceptance of IND application for ADXS-PSA combination trial
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